Does a 150-mg maintenance dose of clopidogrel improve antiplatelet effects compared to a 75-mg dose in high-risk T2DM patients with coronary artery disease?
A 150-mg maintenance dose of clopidogrel improves antiplatelet effects compared to the standard 75-mg dose in T2DM patients with CAD, though high platelet reactivity persists.
A 150-mg maintenance dose of clopidogrel is associated with enhanced antiplatelet effects compared with 75 mg in high-risk T2DM patients. However, enhanced ex vivo platelet reactivity continues to persist, the clinical implications of which are unknown and need to be evaluated in large-scale clinical trials.
Angiolillo et al. (Fri,) studied this question.