HSC-targeted nanoplatform for cascade-responsive imaging of mitochondrial H 2 O 2 -viscosity and synergistic melatonin-based antioxidant therapy in hepatic ischemia-reperfusion injury

Key Points

• The study aims to develop an HSC-targeted nanoplatform for real-time imaging of mitochondrial H2O2 and viscosity dynamics during hepatic ischemia-reperfusion injury.
• Integrated a mitochondrial H2O2/viscosity-responsive fluorescent probe with melatonin.
• Targeted hepatic stellate cells (HSC) for cell-specific imaging and therapy.
• Facilitated simultaneous real-time imaging and antioxidant therapy.
• Successfully enabled real-time imaging of H2O2 and viscosity dynamics in HSC.
• Demonstrated effectiveness in reducing liver injury through ROS scavenging with melatonin.