Liver cell regeneration is a unique and highly coordinated biological process that ensures the restoration of liver structure and function following injury or partial hepatectomy. Unlike most organs, the liver possesses an extraordinary regenerative capacity driven primarily by the proliferation of mature hepatocytes and supported by hepatic progenitor cells under severe conditions. This article explores the molecular mechanisms, cellular pathways, and regulatory factors involved in liver regeneration, including the roles of cytokines, growth factors, and signaling pathways such as Wnt/β-catenin and transforming growth factor-beta. Additionally, the study highlights the clinical significance of liver regeneration in the management of liver diseases, transplantation, and regenerative medicine. Understanding these mechanisms opens new perspectives for therapeutic strategies aimed at enhancing liver repair and improving patient outcomes.
Khamrayev et al. (Fri,) studied this question.