Does the duration of digoxin treatment affect the recurrence of atrial arrhythmias in patients with postoperative atrial fibrillation after coronary bypass?
58 patients during early convalescence after coronary bypass operations, including 43 who developed spontaneous symptomatic postoperative atrial fibrillation requiring digitalization and 15 controls who did not develop spontaneous atrial fibrillation.
Digoxin treatment continued for 8 weeks (n=16), 5 weeks (n=13), or 3 weeks (n=14) following operation.
Patients without postoperative atrial fibrillation (n=15) and comparison between different durations of digoxin therapy (3, 5, or 8 weeks).
Incidence of recurrent atrial arrhythmias (symptomatic and asymptomatic atrial fibrillation) assessed by 24-hour ambulatory Holter monitoring.surrogate
Digoxin therapy for postoperative atrial fibrillation after coronary bypass can be safely discontinued 3 weeks after the operation without significant recurrence of symptomatic atrial fibrillation.
Ambulatory Holter monitoring was performed in 58 patients during the early convalescence after myocardial revascularization in order to determine the incidence of recurrent atrial arrhythmias following treatment for postoperative atrial fibrillation. Fifteen patients who had undergone coronary bypass and had not developed spontaneous atrial fibrillation following operation served as the controls (group 1). The remaining patients developed spontaneous symptomatic atrial fibrillation after coronary bypass that required digitalization for rate control. Sixteen patients (group 2) continued taking digoxin for 8 weeks following operation, 13 patients (group 3) discontinued digoxin treatment 5 weeks following operation, and 14 patients (group 4) discontinued digoxin treatment 3 weeks following operation. Twenty-four-hour Holter monitoring indicated that asymptomatic atrial fibrillation was common in the treatment groups after digitalization just before discharge from hospital. Atrial fibrillation, however, rarely recurred following discharge from hospital and was never symptomatic. Our data indicate that patients who develop spontaneous postoperative atrial fibrillation should be treated with digoxin for 3 weeks following operation and then drug therapy may be discontinued indefinitely.
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LANDYMORE et al. (Tue,) studied this question.
synapsesocial.com/papers/69eedebca84321e0ae63c52a — DOI: https://doi.org/10.1016/1010-7940(91)90191-l
R LANDYMORE
Dalhousie University
F.R. Howell
Hull and East Yorkshire Hospitals NHS Trust
European Journal of Cardio-Thoracic Surgery
Dalhousie University
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