Do abnormal serum cholesterol concentrations and cigarette smoking predispose to specific plaque morphologies in men with coronary disease who die suddenly?
Men with coronary disease who died suddenly
Abnormal serum cholesterol concentrations (particularly elevated total to HDL cholesterol ratio) and cigarette smoking
Plaque morphology (rupture of vulnerable plaques and acute thrombosis)surrogate
Different coronary risk factors are associated with distinct mechanisms of sudden cardiac death, with cholesterol linked to plaque rupture and smoking to acute thrombosis.
Among men with coronary disease who die suddenly, abnormal serum cholesterol concentrations - particularly elevated ratios of total cholesterol to HDL cholesterol - predispose patients to rupture of vulnerable plaques, whereas cigarette smoking predisposes patients to acute thrombosis.
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Allen Burke
University of Vermont
Andrew Farb
Northwestern University
Gray T. Malcom
Preventive Cardiology
New England Journal of Medicine
University of Maryland, Baltimore
Louisiana State University
Armed Forces Institute of Pathology
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Burke et al. (Thu,) studied this question.
synapsesocial.com/papers/69eedf800fb71af24d3117fe — DOI: https://doi.org/10.1056/nejm199705013361802