What question did this study set out to answer?

The study aims to investigate how Pex3p phosphorylation influences the recruitment of Inp2p and Pex19p in peroxisome partitioning.

May 2, 2026

Pex3p phosphorylation modulates recruitment of myosin V adapters Inp2p and Pex19p to regulate peroxisome partitioning in yeast.

Key Points

The study aims to investigate how Pex3p phosphorylation influences the recruitment of Inp2p and Pex19p in peroxisome partitioning.
Examined the role of Pex3p phosphorylation in the recruitment of Inp2p and Pex19p.
Analyzed effects of deleting the phosphorylation loop on peroxisome segregation.
Investigated environmental stimuli impact on Pex3p phosphorylation and subsequent binding dynamics.
Phosphorylation abolished Inp2p binding and reduced Pex19p association with Pex3p.
Deleting the phosphorylation loop completely stopped peroxisome segregation.
Pex3p serves as a membrane anchor essential for the recruitment of Inp2p and Pex19p.

Abstract

. Pex3p is an integral membrane protein that contains a cytosol-exposed surface loop subject to phosphorylation. This loop is essential for the recruitment of both Inp2p and Pex19p. Phosphorylation of serine residues within the loop in response to environmental stimuli abolishes Inp2p binding to, and markedly reduces Pex19p association with, Pex3p, thereby reducing the efficiency of peroxisome partitioning between mother cell and bud. Deleting the loop in Pex3p completely abolishes peroxisome segregation. By serving as a membrane anchor for the recruitment of both inheritance factors Inp2p and Pex19p, Pex3p exerts a critical level of control over peroxisome partitioning. Media: see text Media: see text Media: see text Media: see text Media: see text.

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Cite This Study

Knoblach et al. (Wed,) studied this question.

synapsesocial.com/papers/69f594fc71405d493afffe98 https://doi.org/https://doi.org/10.1091/mbc.e26-02-0078

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