Prochelators modulate azole activity against Candida albicans in a metal-dependent manner

Key Points

• To investigate how prochelators affect the efficacy of azoles against Candida albicans through copper modulation.
• Assess the impact of prochelators on azole activity against Candida albicans
• Measure copper accumulation in fungal cells
• Evaluate fungicidal effects under various copper conditions.
• Prochelators significantly increase copper levels in Candida albicans, enhancing azole activity
• Demonstrated fungicidal effects under copper accumulation conditions, with a notable increase in efficacy.