Are sleep apnea-specific novel hypoxic metrics associated with disturbances in glucose and lipid metabolism in patients with obstructive sleep apnea?
Novel hypoxic metrics (pRED_3p and SBII) correlate with glucose and lipid metabolic dysregulation in OSA, potentially serving as predictive indicators for metabolic risk.
Objective: Obstructive sleep apnea (OSA) has been linked to disturbances in glucose and lipid metabolism. The independent association between sleep apnea-specific novel hypoxic metrics and metabolic dysregulation in OSA, however, remains unclear. Methods: channel. Biochemical parameters were simultaneously assessed. Multiple linear regression models were applied to examine independent associations of pRED₃p, SBII, and apnea-hypopnea index (AHI) with glucose and lipid profiles. Logistic regression was further performed to estimate odds ratios (ORs) for abnormal glucose and lipid parameters across quartiles of pRED₃p, SBII, and AHI. Results: 0. 001). Conclusion: pRED₃p and SBII were associated not only with established glucose and lipid metabolism parameters-including elevated FBG, FIN, HOMA-IR, hypercholesterolemia, hypertriglyceridemia, and elevated LDL-C-but also with composite lipid indices, exhibiting consistent linear trends. Greater OSA severity corresponded to more marked disturbances in glucose and lipid metabolism. These novel hypoxic metrics may serve as predictive indicators for metabolic dysregulation in OSA.
Li et al. (Thu,) studied this question.