Yaksh Chudasama Alzheimer's Affected Protocol (YCAAP) : A Multimodal Systems Framework for Network Stabilization in Alzheimer's Disease.

This work presents the Yaksh Chudasama Alzheimer’s Affected Protocol (YCAAP), a conceptual systems-level framework for understanding and stabilizing Alzheimer’s disease progression. The model reframes Alzheimer’s disease as a nonlinear, feedback-amplifying network involving interacting pathological domains, including endosomal–lysosomal dysfunction, impaired proteostasis, metal ion dyshomeostasis, oxidative stress, chronic neuroinflammation, neurotransmission failure, and environmental modulators. Rather than focusing on single-target therapeutic strategies, the framework proposes that coordinated, partial attenuation across multiple domains may reduce overall network instability and slow disease progression. A biomarker-guided stratification approach is additionally introduced to support adaptive prioritization of pathological axes. This manuscript is hypothesis-generating and intended for academic discussion and further investigation. The proposed framework requires empirical validation and should not be interpreted as clinical or therapeutic guidance.