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This research investigates how genetics relate to cardiorespiratory fitness (CRF) and its effects on health outcomes.

May 8, 2026Open Access

Evaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health

This research investigates how genetics relate to cardiorespiratory fitness (CRF) and its effects on health outcomes.
Evaluated genome-wide polygenic scores (PGS) for their association with CRF phenotype.
Analyzed links between genetic variations and incidences of Type 2 Diabetes (T2D).
Genome-wide PGS accounts for a small portion of CRF phenotype variation.
Some links between genetic factors and T2D incidence were detected.

. The genome-wide PGS explains only a fraction of the CRF phenotype, yet some small associations were observed, particularly for T2D incidence.

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Scandinavian Journal of Medicine and Science in Sports

Norwegian University of Science and Technology

Institute for Molecular Medicine Finland

University of Jyväskylä

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