Synthesis of condensed chiral pyranopyran derivatives with antiproliferative activity using domino Knoevenagel-IMHDA sequences

Key Points

• The research aims to develop chiral pyranopyran derivatives with antiproliferative activity through innovative synthetic methods.
• Pentacyclic frameworks were synthesized using domino Knoevenagel-IMHDA sequences.
• The reaction combines pyrano[4,3-b]pyran units with pyrone/pyridone and tetrahydroquinoline/chroman subunits.
• The synthesized compounds exhibited significant antiproliferative activity against various cancer cell lines.
• Targeted structures showed enhanced effectiveness compared to standard treatments.