Rise of Neisseria gonorrhoeae with mosaic penA-34, France, 2018–2023

Key Points

• The study aims to analyze the rise of antimicrobial resistance in Neisseria gonorrhoeae in France over five years.
• Conducted surveillance of antimicrobial resistance from 2018 to 2023.
• Monitored the distribution of cefixime MIC levels and associated genotypes.
• Analyzed the rise of specific clones carrying mosaic penA-34 alleles.
• The percentage of gonorrhoeae isolates with cefixime MIC ≥ 0.032 mg/L increased from 8.1% (2018–2022) to 23.5% (2023).
• Expansion of clones ST1580 and ST16676 was identified as responsible for the rise in resistance.
• Both clones carried distinct mosaic penA-34 alleles, indicating evolving resistance determinants.

Abstract