What question did this study set out to answer?

This report aims to highlight the differences in PET imaging results for prostate cancer metastases based on PSMA expression.

May 8, 2026

Widespread Prostate Cancer Osseous Metastases: Negative on 18 F-Piflufolastat PET but Positive on 18 F-Fluciclovine PET

Key Points

This report aims to highlight the differences in PET imaging results for prostate cancer metastases based on PSMA expression.
Case presentation of an 84-year-old man diagnosed with prostate cancer.
Analysis of PET imaging results using both piflufolastat and fluciclovine.
Comparison of avidity and nonavidity of metastases in relation to PSMA expression.
PET imaging with 18F-Piflufolastat was negative for metastases.
PET imaging with 18F-Fluciclovine was positive for metastases.
Findings indicate the presence of metastases that do not express PSMA.

Abstract

Although most prostate cancer metastases are avid on prostate-specific membrane antigen (PSMA)–targeted PET (11,22), nonavid prostate cancer metastases may occur when the malignancy does not express PSMA (33). Here, we present images of an 84-y-old man who was diagnosed with prostate

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Authors

Gary A. Ulaner

University of Southern California

Richard Lam

Oncology Specialists

Journals

Journal of Nuclear Medicine

Actions

Institutions

University of Southern California

Oncology Specialists

Hoag Orthopedic Institute

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Analyzing shared references across papers

Widespread Prostate Cancer Osseous Metastases: Negative on 18 F-Piflufolastat PET but Positive on 18 F-Fluciclovine PET

Key Points

Abstract

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Discussion

Authors

Journals

Actions

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References and Citations

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