September 27, 1962
View Full PaperAugmentation of the Plasma Nor-Epinephrine Response to Exercise in Patients with Congestive Heart Failure
Structured PICO
Does muscular exercise augment the plasma nor-epinephrine response in patients with congestive heart failure?
P
Population
Patients with congestive heart failure
I
Intervention
Muscular exercise
O
Outcome
Plasma nor-epinephrine responsesurrogate
This study investigates the role of the sympathetic nervous system, as measured by plasma nor-epinephrine response, during exercise in patients with congestive heart failure.
Abstract
THE manner in which the cardiovascular system responds to the increased metabolic demands of muscular exercise is of considerable interest to the clinician and physiologist. It has been suggested that the sympathetic nervous system plays an important part in mediating this response in normal man.1 2 3 4 5 In patients in whom the cardiac reserve is diminished, the normal increase of cardiac output during exercise is attenuated, or even abolished.6 , 7 It is not known to what extent the sympathetic nervous system is called into play under these circumstances. Diminished activity of this important reserve mechanism could be a factor in the abnormal cardiac . . .