Background/Aims: The purpose of clinical trial to evaluate the effect of apple cider vinegar on VEGF165 and glucose level in type-II diabetes Mellitus (DM) patients. Methods: A clinical randomized trial with non-probability convenient sampling technique study was conducted on 110 eligible types-II diabetes Mellitus patients who were failed to control their glucose level and they were suggested for cataract (senile) surgery. 15-20 ml apple cider vinegar in 200 ml water before sleep at night for 6 months (follow-up after each 3 months). HbA1C, Fasting Blood Sugar, VEGF165 tests were performed Pre and Post operatively and analyzed using SPSS version 21. Result: Total 110 diabetic type-II patients who were (NPDR) in both eyes, high ration of age between 51-60 about 54.4%, females were 61.5% and majority were illiterate about 37.2%. about 58.2% patients strictly follow their medication, about 53.1% patients strictly follow their diet plane and about 48.2% patients strictly intake apple cider vinegar daily. Significant mean changes were found in VEGF165 (p<0.002), HbA1C (p<0.023), blood sugar fasting (p<0.012). Conclusion: Apple cider vinegar regularly is most effective in controlling diabetes and unusual production of VEGF165 (protein) of retina in DM type-II patient and control the worse condition of the eye moreover ophthalmologist can easily operate the cataract surgery and remove the dense cataract of the eye.
Memon et al. (Tue,) studied this question.