Background/Objectives: Vitamin D deficiency is highly prevalent among young Indian women. This study evaluated the dose–response effects of varying levels of daily oral vitamin D3 intake on serum 25-hydroxyvitamin D 25(OH)D concentrations and related bone biomarkers in vitamin D-deficient and insufficient young women. Methods: In a 12-week, double-blind, randomized controlled trial conducted in urban Bangalore, 108 non-pregnant, non-lactating women aged 18–35 years with serum 25(OH)D 98%) across all groups, and no serious adverse events were reported. Conclusions: Daily dietary intake of vitamin D3 at doses of 400–800 IU for 12 weeks significantly improved serum 25(OH)D concentrations in vitamin D-deficient young Indian women. While PTH levels decreased over time, effects on bone turnover markers were modest and not dose specific. A daily dose of 800 IU/day was the most effective, achieving vitamin D sufficiency in 65% of participants.
Peris et al. (Wed,) studied this question.
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