Emerging evidence suggests that psychological trauma, chronic stress, and unresolved emotional conflict may influence cancer-related processes through neuroendocrine and immunological pathways. However, the clinical relevance of trauma-related psychological profiles in oncology remains insufficiently defined, particularly in women with breast and gynecological cancers. This exploratory observational study included 135 women with breast, cervical, ovarian, and endometrial cancers undergoing multimodal oncological treatment. Psychological assessments were performed using validated instruments, including the PTSD Checklist (PCL), Hamilton Anxiety and Depression Scales (HAM-A, HAM-D), the Adult Attachment Scale (AAS), and a Lazarus-based checklist of stressful life events to assess cumulative stress exposure. Descriptive and exploratory analyses were conducted to identify clinically relevant patterns. A high prevalence of anxiety, depressive symptoms, and trauma-related distress was observed. Insecure attachment patterns were frequent and associated with increased psychological burden. Many patients reported moderate-to-high cumulative stress exposure, suggesting broader vulnerability profiles characterized by emotional dysregulation. These findings support a biopsychosocial model in which trauma, attachment insecurity, and cumulative stress are associated with psychological vulnerability in oncology. Although causal relationships cannot be established, these factors may influence coping and adaptation to disease. Integrating trauma-informed psychological assessment into oncology care may enhance patient-centered management.
Meoded et al. (Wed,) studied this question.