January 1, 2002

الأدوية كركائز ومثبطات ومحفزات لبروتين-ج- P

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Abstract

في البشر، يوجد نوعان من ناقلات بروتين-ج- P (P-gp) مشفرة بواسطة MDR1 (PGY1) و MDR3 (المعروفة أيضًا باسم MDR2 و PGY3) وتقع متجاورة في المنطقة الكروموسومية 7q21 12. الجين المشفر ...

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درس ريتشارد ب. كيم (الثلاثاء) هذا السؤال.

synapsesocial.com/papers/69ff55fbef8139f8ff775717 https://doi.org/https://doi.org/10.1081/dmr-120001389

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1Secretion of Sparfloxacin from the Human Intestinal Caco-2 Cell Line Is Altered by P-Glycoprotein Inhibitors1998 · 51 citations
2Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.1996 · 498 citations
3HumanMDR1and Mousemdr1aP-Glycoprotein Alter the Cellular Retention and Disposition of Erythromycin, but Not of Retinoic Acid or Benzo(a)pyrene1998 · 94 citations
4The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.1998 · 1,063 citations
5Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins1997 · 941 citations

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