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At odds with long-standing convictions, it is now clear that tumors are not immunologically silent entities. We have recently demonstrated that the immune system can selectively detect and eliminate hyperploid (pre-) malignant cells, thus delineating a novel mechanism of immunosurveillance against tumorigenesis. Malignant cells of different histological origin share a set of common features, including an impressive, growth factor-independent proliferative potential as well as an increased resistance to potentially lethal stimuli. At least in part, such characteristics stem from mutations in the genome of (pre-)neoplastic cells that cause either the loss-of-function of oncosuppressor genes and/or the (hyper)activation of proto-oncogenes 1. Along with tumor progression, newly-formed malignant cells continue
Senovilla et al. (Tue,) studied this question.