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Echocardiographic quantitation of myocardial deformation has been one of the most significant developments in our field over the last decade, with important applications in basic myocardial mechanics, ischaemic heart disease, cardiomyopathies, valvular heart disease, diastolic function, and in detecting pre-clinical myocardial dysfunction such as in cardiotoxicity in cancer chemotherapy and valvular regurgitation. Unfortunately, several investigators have documented a relatively poor reproducibility when strain is calculated using echocardiographic equipment from different vendors, an issue that threatens widespread clinical application of this important new technology.
Thomas et al. (Thu,) studied this question.