What question did this study set out to answer?

To establish a quantitative theoretical framework for ultrasound-switchable fluorescence (USF) imaging and identify its potential for distinguishing features based on signal velocity.

May 10, 2026Open Access

Dynamic models for ultrasound-switchable fluorescence

Key Points

To establish a quantitative theoretical framework for ultrasound-switchable fluorescence (USF) imaging and identify its potential for distinguishing features based on signal velocity.
Developed a dynamic sensitivity matrix for USF imaging.
Conducted a theoretical analysis of signal velocity.
Evaluated tomographic reconstruction approaches for deep-tissue imaging.
Velocity-based analysis allows for differentiation of indistinguishable features within the focus.
Dynamic sensitivity matrix supports improved tomographic reconstruction.
Potential for advancing deep-tissue super-resolution imaging techniques.

Abstract

This study provides a quantitative theoretical basis for dynamic USF imaging and highlights the additional structural information contained in signal velocity. The results suggest that velocity-based analysis may enable differentiation of otherwise indistinguishable features within the focal volume. The derived dynamic sensitivity matrix further supports tomographic reconstruction and may facilitate future deep-tissue super-resolution strategies.

Dynamic models for ultrasound-switchable fluorescence

Key Points

Abstract

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