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This research investigates how bruceine D affects the progression of non-small-cell lung cancer (NSCLC) by targeting STAT3.

May 10, 2026Open Access

Inhibition of STAT3-mediated glycolysis by bruceine D suppresses non-small-cell lung cancer progression in vitro and in vivo

Key Points

This research investigates how bruceine D affects the progression of non-small-cell lung cancer (NSCLC) by targeting STAT3.
Evaluated bruceine D in a mouse xenotransplantation model
Analyzed tumor growth and viability of NSCLC cells
Utilized Western blotting to assess STAT3 phosphorylation and nuclear translocation
Bruceine D significantly reduced NSCLC cell viability and promoted apoptosis in vitro
In vivo, it inhibited tumor growth in mouse xenograft models
Direct binding of bruceine D to STAT3 was confirmed, leading to reduced glycolysis

Abstract

BACKGROUND: , a plant widely used in traditional Chinese medicine. METHODS: was evaluated in a mouse xenotransplantation model. RESULTS: Bruceine D significantly reduced the viability of NSCLC cells, promoted apoptosis, and inhibited the growth of tumors in a mouse xenograft model. Bruceine D was found to bind directly to STAT3, inhibiting glycolysis in NSCLC cells. Western blotting results suggested that the antitumor effects of bruceine D might be mediated by the inhibition of the phosphorylation and nuclear translocation of STAT3. CONCLUSION: . Bruceine D has potential application prospects in the field of anti-NSCLC therapy.

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Zhu et al. (Fri,) studied this question.

synapsesocial.com/papers/6a0020cec8f74e3340f9baec https://doi.org/https://doi.org/10.1080/15384047.2026.2665867

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