PURPOSE: To develop a cubic-millimeter, high-resolution CEST MRI sequence with enhanced efficiency and quantitative stability. METHODS: and CEST datasets. Feasibility was evaluated in phantoms and preliminary patient studies. RESULTS: and Z-spectral measurements with inherently co-registered datasets. Preliminary patient imaging revealed heterogeneity within the diseased region and exchange-dependent relaxation contrast, clearly differentiating it from contralateral normal tissue. CONCLUSION: -CEST MRI sequence provides efficient, artifact-reduced, and quantitatively reliable high-resolution imaging in a single acquisition, advancing the feasibility of quantitative CEST analysis.
Kim et al. (Fri,) studied this question.