Construction of viscosity-sensitive RNA fluorescent probes and their application in inflammtation imaging

Key Points

• The study aims to develop RNA fluorescent probes that are sensitive to viscosity changes and to apply them in inflammation imaging.
• Constructed RNA probes targeting viscosity changes
• Applied probes in imaging model systems for inflammation detection
• Assessed performance based on viscosity fluctuations correlated with inflammation
• Probes successfully detected viscosity changes in inflammation models
• Demonstrated high sensitivity and specificity for inflammatory conditions
• Showcased potential for assessing nucleolar dysfunction related to major diseases