Key points are not available for this paper at this time.
]pyridines containing both axially and centrally chiral elements in high yields and excellent stereoselectivities (up to >99% yield, 91:9 dr, 98% ee). A control experiment revealed that this process proceeded through a multistep 2 + 2 cycloaddition/retroelectrocyclization/tautomerism/1,6-conjugate addition cascade.
Xiao et al. (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: