Dimeric DNA Tetrahedron-Incorporated Nanopipette: Split Aptamer-Mediated Signal Amplification for Ultrasensitive Small-Molecule Detection

Key Points

• To explore the use of dimeric DNA tetrahedron-incorporated nanopipettes for sensitive detection of small molecules.
• Developed a nanopipette amplifier incorporating dimeric DNA tetrahedrons.
• Applied aptamer-mediated signal amplification to boost sensitivity for small-molecule detection.
• Achieved high-precision detection of clinically relevant molecules using the nanopipette system.