December 11, 2019Open Access

CXCR4/TGF-β1 mediated hepatic stellate cells differentiation into carcinoma-associated fibroblasts and promoted liver metastasis of colon cancer

HTHao‐Xiang TanBeijing Technology and Business University WGWei-Zhi GongHunan Normal University KZKai ZhouXinjiang Medical University

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Abstract

: These results indicated that CXCR4/TGF-β1 axis plays an important role in CRC liver metastasis through mediating HSCs differentiation into CAFs, providing preclinical evidences that blockade of the axis might be beneficial for anti-metastasis therapy in CRC.

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Tan et al. (Wed,) studied this question.

synapsesocial.com/papers/6a01876c0cec8eebbd5c9aa2 https://doi.org/https://doi.org/10.1080/15384047.2019.1685157

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