Sequential chemotherapy followed by standard AVD resulted in complete remission and progressive recovery of ejection fraction in a 62-year-old woman with primary cardiac classical Hodgkin lymphoma.
Case Report (n=1)
This case highlights the rare presentation of primary cardiac classical Hodgkin Lymphoma and its successful treatment with chemotherapy leading to complete remission and LVEF recovery.
Background: Primary cardiac lymphoma (PCL) is a rare extranodal non Hodgkin Lymphoma (NHL), characterized by a primary lesion occuring in the heart and/or in the pericardium. The majority of PCLs are non-Hodgkin diffuse large B cell lymphoma (DLBCL), even if other NHL histologies have been described. Patients with PCL experience heterogeneous clinical signs or symptoms (i.e. dyspnea, thoracic pain, electrocardiographic (EKG) abnormalities, and heart failure), often-delaying correct diagnosis and treatment. The prognosis of PCLs is poor and median overall survival is less than 12 months. We report a case of particular histology for a PCL, a classical Hodgkin Lymphoma. Case Report: In June 2021, a 62-year-old woman experienced rapid onset dyspnea and edema of legs. Echocardiogram and Cardiac Magnetic Resonance showed a reduction of LVEF (25%) with an obstruction in right ventricle, and then a Positron Emission Tomography showed an abnormal uptake in the heart. A mediastinal biopsy wasper formed with a diagnosis of classical HL, Ann Arbor IIEA stage. A systematic approach with a pre-phase and a subsequent sequential chemotherapy administration was chosen for the first cycle of chemotherapy, then from the second cycle standard AVD was administered. During the therapy, the patient was closely monitoring for risk of arrhytmia or heart failure. The EoT PET-CTshowed a complete remission of cHL and the Ecochardiogram a progressive recovery of EF.
Muzi et al. (Fri,) conducted a case report in Primary Cardiac Lymphoma (classical Hodgkin Lymphoma) (n=1). Sequential chemotherapy and standard AVD was evaluated on Clinical outcome (remission and ejection fraction recovery). Sequential chemotherapy followed by standard AVD resulted in complete remission and progressive recovery of ejection fraction in a 62-year-old woman with primary cardiac classical Hodgkin lymphoma.