The renin inhibitor EMD 58265 produced greater hypotension than the ACE inhibitor enalaprilat in anesthetized rabbits, which was associated with decreased plasma AI but not AII.
Does the renin inhibitor EMD 58265 compared to enalaprilat affect arterial blood pressure and renal blood flow differently in anesthetized rabbits?
In a rabbit model, renin inhibition caused greater hypotension than ACE inhibition, associated with decreased plasma AI but not AII.
GREATER HYPOTENSIONDURINGRENIN THAN ACEINHIBITIONASSOCIATEDWITHDECREASED PLASMAAI, BUT NOT AIL Zimmerman*& PC Birt.Universityof Minnesota,Minneapolis,MN 55455. Hollenberg and Fisber (Hypertension 26:602-609, 1995) prwented evidence for a greater increase in renal plasmaflow witbthe administrationof reninthanACE inhibitors.This provocativeresult promptedus to compare the arteriatbloodpressure(BP)and renal bloodflow (RBF) effects of the renininhibitor,EMD 58265 (2-2.5 mgkg) and enalaprilat(2 mgkg) given IV in the anesthetized rabbit. BP, RBF (by electromagnetic flowmetry), and plasma AI and AfI levels were measured in New Zealand White rabbits anesthetizedwith sodiumpentobarbitsLThe data from5 2-lddneyone-clipGoldblatt hypertensive and2 normotmrsive rabbitswerepooled. EMR BP (mmHe) 107+12 89i9t 75*1O* ft#JIll&) 37k6 4(MI0 32*4 1007+676 1923*865 32*4* .., AII (P@td) 381*189 222k145f 440*354
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A Thu, study conducted a other in Hypertension (n=7). EMD 58265 vs. Enalaprilat (2 mg/kg IV) was evaluated on Arterial blood pressure and renal blood flow. The renin inhibitor EMD 58265 produced greater hypotension than the ACE inhibitor enalaprilat in anesthetized rabbits, which was associated with decreased plasma AI but not AII.