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Epilepsy is a disease characterized by central nervous system dysfunction induced by an excessive synchronous discharge of cerebral neurons, with diverse etiologies and complicated pathogenesis, and is difficult to treat. Ferroptosis is a newly defined iron-dependent programmed cell death, characterized by excessive accumulation of lipid peroxides and reactive oxygen species. Studies have shown that ferroptosis is involved in the occurrence and development of epilepsy, and this has become a research focus. In this article, we review and summarize the following aspects: the outline of ferroptosis, the mechanisms of ferroptosis, and the role of ferroptosis in epilepsy, which provide a reference for further exploration of the pathophysiological mechanisms of epilepsy and search of novel therapeutic targets.
Liu et al. (Thu,) studied this question.