Cortex-wide topography of 1/f-exponent in Parkinson’s disease

- f is the frequency, κ and λ are the fitting parameters-to the MEG power spectrum and studied its relationship with age and Unified Parkinson's Disease Rating Scale (UPDRS). Consistent with previous results, the most significant spectral changes were observed in the high theta/low-alpha band (7-10 Hz) in all brain regions. Furthermore, analysis of the aperiodic part of the spectrum showed that in all but frontal regions λ was significantly larger in PD patients than in control subjects. Our results indicate that PD is associated with significant changes in aperiodic activity across the whole neocortex. Surprisingly, even early sensory areas showed a significantly larger λ in patients than in healthy controls. Moreover, λ was not affected by the Levodopa medication. Finally, λ was positively correlated with patient age but not with UPDRS-III. Because λ is closely associated with excitation-inhibition balance, our results propose new hypotheses about neural correlates of PD in cortical networks.