What question did this study set out to answer?

This research aims to understand the role of ANT family proteins and CypD in mitochondrial permeability transition.

August 2, 2019Open Access

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

Key Points

This research aims to understand the role of ANT family proteins and CypD in mitochondrial permeability transition.
Generated triple null mouse embryonic fibroblasts by deleting ANT family and CypD.
Assessed MPTP activity in these fibroblasts.
Triple null fibroblasts displayed a complete loss of MPTP activity.
Findings indicate that ANTs and another unidentified component are essential for MPTP functionality.

Abstract

triple null mouse embryonic fibroblasts showed a loss of MPTP activity. Our findings suggest a model for the MPTP consisting of two distinct molecular components: The ANTs and an unknown species requiring CypD.

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