What question did this study set out to answer?

To highlight a rare case of untreated mediastinal small cell carcinoma with slow progression.

May 13, 2026Respirology Case Reports0 citationsOpen Access

Extraordinarily Slow, Non‐Metastatic Progression of Primary Mediastinal Small Cell Carcinoma

SASeo In AhnJeonbuk National University JJJae Seok JeongChungbuk National University MCMyeong Ja ChungChonbuk National University Hospital

Key Points

To highlight a rare case of untreated mediastinal small cell carcinoma with slow progression.
Long-term CT follow-up of a rare case of primary mediastinal small cell carcinoma.
Assessment of tumor characteristics over time.
The carcinoma showed unusually slow progression without metastasis.
Diagnostic considerations for malignancy versus benign lymphadenopathy were emphasized.

Abstract

ABSTRACT We report a rare untreated mediastinal small cell carcinoma (MSCC) showing unusually slow, non‐metastatic progression over long‐term CT follow‐up. MSCC should be considered in mediastinal mass differentials. Distinguishing malignancy from benign lymphadenopathy in patients with lung disease is essential to avoid diagnostic delays.

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