اكتشاف قائم على الفراجمنتات لمركب MRTX1719، مثبط قاتل اصطناعي معقد PRMT5•MTA لعلاج السرطانات المحذوفة MTAP

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Fragment-based lead discovery grows up2012 · 214 citations
2. 2METEOR-1: A phase I study of GSK3326595, a first-in-class protein arginine methyltransferase 5 (PRMT5) inhibitor, in advanced solid tumours2019 · 133 citations
3. 3Revealing Atropisomer Axial Chirality in Drug Discovery2011 · 520 citations
4. 4Preparation and Reactions of Heteroarylmethylzinc Reagents2014 · 29 citations
5. 5MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis2016 · 447 citations