Action potential shortening via Kv11.1 channel activation suppressed or completely eliminated calcium and action potential duration alternans in atrial myocytes and isolated hearts.
Does action potential shortening via Kv11.1 channel activation suppress atrial calcium and T-wave alternans in isolated hearts and myocytes?
Action potential shortening represents a potential therapeutic strategy to suppress atrial alternans, thereby potentially reducing the risk of atrial fibrillation.
KEY POINTS: conductances represents a promising strategy to suppress alternans, and thus reducing a risk factor for atrial fibrillation. ABSTRACT: alternans was caused by the changes in AP morphology. Finally, activation of Kv11.1 channel significantly attenuated or even abolished atrial T-wave alternans in isolated Langendorff perfused hearts. In summary, AP shortening suppressed or completely eliminated both CaT and APD alternans in single atrial myocytes and atrial T-wave alternans at the whole heart level. Therefore, we suggest that AP shortening is a potential intervention to avert development of alternans with important ramifications for arrhythmia prevention and therapy.
Kanaporis et al. (Fri,) conducted a other in Atrial calcium alternans. Action potential shortening (Kv11.1 channel activation) was evaluated on Atrial T-wave, CaT, and APD alternans. Action potential shortening via Kv11.1 channel activation suppressed or completely eliminated calcium and action potential duration alternans in atrial myocytes and isolated hearts.