Advancements in high-frequency ultrasound have transformed diagnostic imaging, enabling precise, non-invasive characterization of tissue and disease phenotypes. VisualSonics' innovative product portfolio has been instrumental in helping researchers advance the field of super-resolution imaging. From early breakthroughs with the Vevo 2100 mapping individual microbubbles in circulation, to generating super-resolution volumetric datasets with the Vevo 3100, and producing angled plane waves using VADA on the Vevo F2, researchers have consistently pushed the limits of these imaging systems to achieve unprecedented precision in microvascular resolution. Complementary multi-modal imaging with Vevo LAZR photoacoustic systems further enhances research by real-time, high-resolution molecular and functional data, expanding applications in translational and preclinical settings. Despite these advancements, challenges such as long acquisition times, labor-intensive postprocessing, motion sensitivity, and contrast dependence persist. Emerging technologies, including increased channel boards for ultrafast imaging, aim to address these limitations by improving temporal resolution, accelerating data collection, and widening imaging capabilities. Super-resolution imaging, with its ability to visualize subtle tissue variations and detailed microvasculature, continues to hold immense clinical and commercial potential, driving new frontiers in diagnostic and therapeutic applications while addressing critical hurdles in biomedical imaging.
Burris et al. (Wed,) studied this question.