Does greater daily glucose variability and lower time in range associate with greater aortic stiffness?
Greater daily glucose variability and lower time in range are independently associated with greater aortic stiffness, suggesting they may be potential therapeutic targets to prevent cardiovascular disease.
AIMS: CVD is the main cause of morbidity and mortality in individuals with diabetes. It is currently unclear whether daily glucose variability contributes to CVD. Therefore, we investigated whether glucose variability is associated with arterial measures that are considered important in CVD pathogenesis. METHODS: ) with carotid-femoral pulse wave velocity (cf-PWV), carotid distensibility coefficient, carotid intima-media thickness, ankle-brachial index and circumferential wall stress via multiple linear regression. RESULTS: : -0.145 m/s -0.252, -0.038 p = 0.008) were statistically significantly associated with higher cf-PWV. Such consistent associations were not observed for the other arterial measures. CONCLUSIONS: to prevent CVD.
Foreman et al. (Sat,) studied this question.