Computational models including all side branches are required for precise computation of shear stress and pressure gradient, whereas models omitting side branches overestimate outflow and shear stress.
Does including all side branches in 3D hemodynamic models improve the accuracy of shear stress and pressure gradient computation compared to models without them?
Accurate 3D hemodynamic modeling of coronary arteries requires the inclusion of all side branches to prevent overestimation of shear stress and volumetric outflow.
Genesis of atherosclerotic lesions in the human arterial system is critically influenced by the fluid mechanics. Applying computational fluid dynamic tools based on accurate coronary physiology derived from conventional biplane angiogram data may be useful in guiding percutaneous coronary interventions. The primary objective of this study is to build and validate a computational framework for accurate personalized 3-dimensional hemodynamic simulation across the complete coronary arterial tree and demonstrate the influence of side branches on coronary hemodynamics by comparing shear stress between coronary models with and without these included. The proposed novel computational framework based on biplane angiography enables significant arterial circulation analysis. This study shows that models that take into account flow through all side branches are required for precise computation of shear stress and pressure gradient whereas models that have only a subset of side branches are inadequate for biomechanical studies as they may overestimate volumetric outflow and shear stress. This study extends the ongoing computational efforts and demonstrates that models based on accurate coronary physiology can improve overall fidelity of biomechanical studies to compute hemodynamic risk-factors.
Vardhan et al. (Thu,) conducted a other in Coronary artery disease. Computational models with all side branches vs. Models without side branches was evaluated on Shear stress and pressure gradient. Computational models including all side branches are required for precise computation of shear stress and pressure gradient, whereas models omitting side branches overestimate outflow and shear stress.
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