Abstract Background Minimizing visible scarring is a critical concern in facelift surgeries. Combining surgical techniques with adjunctive treatments, such as polyrevitalizing solutions (PRS), may enhance wound healing. Polyrevitalizing solutions, a solution with hyaluronic acid and bioactive molecules, has shown potential to improve skin quality and healing. Objectives The analysis aimed to assess the effectiveness of PRS injections before and after facelift surgery in improving scar healing and skin quality. Methods Seven patients undergoing facelift surgery participated in this split-face case series. One side of the face received PRS injections (5 sessions: 1 week before surgery, on the day of surgery, and at 2 weeks, 1 month, and 45 days post-surgery), while the other side served as a control. Scar healing was assessed using the Patient and Observer Scar Assessment Scale (POSAS) and Global Aesthetic Improvement Scale at multiple time points. Skin hydration, firmness, homogeneity, and radiance were also evaluated. Results The PRS-treated side showed significantly faster improvements in POSAS scores by Day 10, compared to Day 90 on the untreated side. Scar characteristics, such as vascularity, thickness, relief, and pliability, improved earlier on the treated side. Skin quality parameters, including hydration, firmness, and radiance, were significantly better at 60 days on the treated side. Global Aesthetic Improvement Scale scores indicated greater patient and investigator satisfaction on the PRS-treated side. Conclusions In this pilot study, combining PRS injections with facelift surgery significantly improved scar healing and skin quality, providing a promising adjunctive treatment for better aesthetic outcomes. Level of Evidence: 3 (Therapeutic) For image description, please refer to the figure legend and surrounding text.
Piovano et al. (Thu,) studied this question.