Integrin‐Targeted Delivery of Redox Homeostasis Regulating Lanthanide‐Based Composite Nanoplatform for Deep Self‐Enhanced Photodynamic/H 2 S Gas Synergistic Therapy via 1530 nm Activation

Key Points

• To investigate the effectiveness of an integrin-targeted lanthanide-based nanoplatform for enhancing photodynamic therapy and gas therapy in tumors.
• Utilized cRGD-PEG for active targeting of UMDP to tumor sites.
• Assessed the gas therapy effect from the reaction of DATS with GSH.
• Examined tissue penetration depth capabilities of the nanoplatform.
• Demonstrated improved accumulation of UMDP in tumor locations through cRGD-PEG targeting.
• Showed enhanced photodynamic therapy effectiveness when combined with gas therapy.
• Achieved deeper tissue penetration compared to traditional approaches.