A history of emotional vasovagal syncope was independently associated with an increased risk of cardiovascular events in later life (HR 1.63; 95% CI 1.27-2.09; P<0.001).
Cohort (n=3,288)
Is a history of emotional vasovagal syncope associated with an increased risk of cardiovascular events in later life among cardiologic outpatients?
A history of emotional vasovagal syncope, but not orthostatic vasovagal syncope, is independently associated with an increased risk of coronary events in later life, particularly in men.
Effect estimate: HR 1.63 (95% CI 1.27-2.09)
p-value: p=<0.001
BACKGROUND: The aim of the study was to assess whether history of vasovagal syncope (VVS) mediated by emotional (emotional VVS) or orthostatic stress (orthostatic VVS) is associated with an increased risk of cardiovascular (CV) events in later life. METHODS: Retrospective analysis based on medical records of the consecutive 3,288 cardiologic outpatients (mean age, 61 ± 12 years; 43% men). RESULTS: A total of 254 patients (7.7%) reported emotional VVS, whereas 294 (9.0%) had history of orthostatic VVS. First-ever syncopal episode was reported at a median age of 16 years (interquartile range IQR, 12 years to 28 years), and the median total number of episodes was two (IQR, 1 to 5). There were 779 patients (23.7%) with at least one CV event, and the median age for the first CV event was 59 years (IQR, 52 years to 67 years). In the fully adjusted model, history of emotional VVS was predictive of CV event (hazard ratio 95% confidence interval: 1.63, 1.27-2.09; P < 0.001), myocardial infarction (1.99, 1.49-2.66; P < 0.001), and percutaneous coronary intervention (1.84, 1.31-2.60; P = 0.001). There was one significant interaction (P = 0.07) between history of emotional VVS and gender. Emotional VVS was predictive of CV event in men (1.89 1.41-2.53; P < 0.001) but not in women (1.24 0.79-1.94; P = 0.35). CONCLUSIONS: History of emotional but not orthostatic VVS is independently associated with increased risk of coronary events in later life. The relationship between predisposition to emotional VVS in adolescence and development of cardiovascular disease requires further studies.
Zyśko et al. (Wed,) conducted a cohort in Vasovagal syncope (n=3,288). History of emotional vasovagal syncope vs. No history of emotional vasovagal syncope was evaluated on Cardiovascular (CV) events (HR 1.63, 95% CI 1.27-2.09, p=<0.001). A history of emotional vasovagal syncope was independently associated with an increased risk of cardiovascular events in later life (HR 1.63; 95% CI 1.27-2.09; P<0.001).