Defective sarcomere biophysical signals and altered mechano-transduction in hypertrophic cardiomyopathy drive early diastolic dysfunction, defective arteriogenesis, and fibrosis.
Absolute Event Rate: 0% vs 0%
We conclude that those early mechanisms that presage hypertrophic remodeling in HCM include defective biophysical signals within the sarcomere that drive diastolic dysfunction, impacting coronary flow dynamics, defective arteriogenesis and fibrosis. Changes in mechano-transduction signaling between the different cellular compartments contribute to the pathogenesis of HCM.
Langa et al. (Fri,) reported a other. Defective sarcomere biophysical signals and altered mechano-transduction in hypertrophic cardiomyopathy drive early diastolic dysfunction, defective arteriogenesis, and fibrosis.
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