The shortened 7-item Seattle Angina Questionnaire (SAQ-7) demonstrated high concordance (0.88-1.00) with the original SAQ domains and high reproducibility (ICC ≥0.78) in patients with CAD.
Observational (n=10,408)
Yes
BACKGROUND: Clinical trials and national performance measures increasingly mandate reporting patients' perspectives of their health status: their symptoms, function, and quality of life. Although the Seattle Angina Questionnaire (SAQ) is a validated disease-specific health status instrument for coronary artery disease (CAD) with high test-retest reliability, predictive power, and responsiveness, its use in routine clinical practice has been limited, in part, by its length (19 items). METHODS AND RESULTS: Using data from 10 408 patients with CAD from 5 multicenter registries, we derived and validated a shortened version of the SAQ (SAQ-7) among patients presenting with stable CAD, undergoing percutaneous coronary intervention, and after acute myocardial infarction. We examined the psychometric properties of the SAQ-7 as compared with the full SAQ. Seven items from the Physical Limitation, Angina Frequency, and Quality of Life domains were identified for the SAQ-7, with high levels of concordance (0.88-1.00) with each original SAQ domain. The SAQ-7 demonstrated good construct validity (compared with Canadian Cardiovascular Society class for angina), with a correlation of 0.62 and 0.38 for patients with stable CAD and undergoing percutaneous coronary intervention, respectively. It was highly reproducible in patients with stable CAD (intraclass correlation, ≥0.78) and exhibited excellent responsiveness in patients after percutaneous coronary intervention (≥18 points in each SAQ domain). Finally, the SAQ-7 was predictive of 1-year mortality and readmission. CONCLUSIONS: To increase the feasibility of measuring patient-reported outcomes in patients with CAD, we developed and validated a shortened 7-item SAQ instrument for use in clinical trials and routine care.
Chan et al. (Mon,) conducted a observational in Coronary artery disease (CAD) (n=10,408). Shortened Seattle Angina Questionnaire (SAQ-7) vs. Full 19-item Seattle Angina Questionnaire (SAQ) was evaluated on Psychometric properties including concordance, construct validity, reproducibility, and responsiveness. The shortened 7-item Seattle Angina Questionnaire (SAQ-7) demonstrated high concordance (0.88-1.00) with the original SAQ domains and high reproducibility (ICC ≥0.78) in patients with CAD.