The ICU environment paradigm as a catalyst for better delirium models

Key Points

• The aim is to improve delirium models in animals by incorporating ICU-like environmental stressors.
• Combined surgery or sepsis with light, noise, sleep disruption, and handling in models.
• Emphasized the relevance of environmental stressors to mimic human ICU conditions.
• Enhanced translational validity of animal models for human ICU delirium.
• Circadian disruption identified as a key area for future mechanistic investigation.