ABSTRACT Flexible multi‐parameter implantable sensors (FMPI‐sensors) are redefining the landscape of personalized medicine. By seamlessly integrating with living tissues, these soft electronic platforms enable real‐time, long‐term, and high‐fidelity monitoring of electrical, biochemical, mechanical, thermal, and optical signals across diverse organ systems. Unlike traditional implants that capture single signals, FMPI‐sensors promote decoding the complex interplay of cues underlying disease onset, progression, and therapeutic response. This review provides a comprehensive framework for understanding the design, application, and integration of FMPI‐sensors. We outline key advances in device architectures, multi‐signal fusion strategies, and intelligent interfaces across the brain, bones, internal organs, subcutaneous tissues, and vasculature. Special emphasis is placed on signal synergy, material innovation, and closed‐loop therapeutic potential. Finally, we discuss future challenges and opportunities in bioadaptive interfaces, autonomous power systems, real‐time AI inference, and regulatory frameworks. FMPI‐sensors are not merely tools for monitoring, they are evolving into intelligent, cooperative extensions of the human body.
Wang et al. (Wed,) studied this question.