What is the clinical evidence from this study?

Study design: Observational. Population: Atrial fibrillation (n=276). Intervention: eNOS level. Primary outcome: Atrial fibrillation recurrence (AUC 0.803, 95% CI 0.751-0.848, p=<0.001).

What question did this study set out to answer?

This study assesses whether low levels of endothelial nitric oxide synthase (eNOS) can predict the recurrence of atrial fibrillation (AF).

May 16, 2026

Low levels of endothelial nitric oxide synthase (eNOS) might serve as a potential indicator for recurrent atrial fibrillation

Q: What are the key findings of this study?

An eNOS level of ≤ 93.4 pg/mL predicted recurrent atrial fibrillation at 6 months with 68% sensitivity and 93.4% specificity (AUC 0.803; 95% CI 0.751-0.848; p<0.001).

Q: What question did this study set out to answer?

This study assesses whether low levels of endothelial nitric oxide synthase (eNOS) can predict the recurrence of atrial fibrillation (AF).

Key Result

An eNOS level of ≤ 93.4 pg/mL predicted recurrent atrial fibrillation at 6 months with 68% sensitivity and 93.4% specificity (AUC 0.803; 95% CI 0.751-0.848; p<0.001).

Key Points

This study assesses whether low levels of endothelial nitric oxide synthase (eNOS) can predict the recurrence of atrial fibrillation (AF).
276 AF patients were analyzed post-hospital admission over six months.
Patients were categorized based on the recurrence of AF during follow-up.
Blood samples were evaluated for eNOS levels along with other biomarkers.
Lower eNOS levels were observed in patients with recurrent AF, compared to those without.
An eNOS cut-off value of ≤ 93.4 pg/mL predicted recurrent AF with 68% sensitivity and 93.4% specificity (AUC: 0.803, 95% CI: 0.751-0.848, p<0.001).

Study Design

Type

Observational (n=276)

Multicenter

Structured PICO

Do lower levels of eNOS predict atrial fibrillation recurrence in patients admitted with AF?

Population

276 patients admitted with atrial fibrillation, mean age 73.1±9.7 years, 50% male.

Intervention

Measurement of endothelial nitric oxide synthase (eNOS) levels

Outcome

Atrial fibrillation recurrence during 6-month follow-upsurrogate

Lower eNOS levels (≤ 93.4 pg/mL) are significantly associated with a higher risk of atrial fibrillation recurrence at 6 months.

Main Result

Effect estimate: AUC 0.803 (95% CI 0.751-0.848)

p-value: p=<0.001

Abstract

Abstract Introduction0.001]). Conclusion This study investigates the role of eNOS activity in AF recurrence for the first time in the literature. It has been shown that lower eNOS levels are linked to a higher risk of AF recurrence.Figure 1:ROC curve analysis of eNOSFor image description, please refer to the figure legend and surrounding text. Graphical Abstract-Central FigureFor image description, please refer to the figure legend and surrounding text.

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Cite This Study

Karakayali et al. (Fri,) conducted a observational in Atrial fibrillation (n=276). eNOS level was evaluated on Atrial fibrillation recurrence (AUC 0.803, 95% CI 0.751-0.848, p=<0.001). An eNOS level of ≤ 93.4 pg/mL predicted recurrent atrial fibrillation at 6 months with 68% sensitivity and 93.4% specificity (AUC 0.803; 95% CI 0.751-0.848; p<0.001).

synapsesocial.com/papers/6a080a71a487c87a6a40c666 https://doi.org/https://doi.org/10.1093/cvr/cvag092.103

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