In patients undergoing lung resection, intraoperative oxygen consumption converged to approximately 1.1 METs under general anesthesia, representing a 29.0% reduction from resting levels.
Observational (n=32)
No
How does intraoperative oxygen consumption (VO₂) under general anesthesia relate to preoperative resting VO₂ in patients undergoing lung resection?
Intraoperative oxygen consumption under general anesthesia converges to approximately 1 MET, largely independent of preoperative resting metabolism.
Effect estimate: r = 0.770
p-value: p=<0.001
Oxygen consumption (VO₂) is a core element of hemodynamic physiology and the metabolic counterpart to oxygen delivery. Modern anesthesia machines enable real-time intraoperative VO₂ estimation, yet its relationship with preoperative metabolic capacity, as characterized by cardiopulmonary exercise testing (CPET), has not been directly examined. This study analyzed preoperative CPET and intraoperative data from adult patients ≥ 20 undergoing lung resection under general anesthesia. Intraoperative VO₂ was estimated from minute ventilation and inspired and end-tidal oxygen fractions. Preoperative and intraoperative VO₂ were summarized, and associations between baseline VO₂ and intraoperative suppression were assessed. Data from 32 patients were analyzed. Preoperative VO₂ at rest, anaerobic threshold, and peak exercise were 1.6 ± 0.4, 5.1 ± 1.9, and 6.1 ± 1.7 metabolic equivalents (METs), respectively. The reduction from resting to intraoperative VO₂ (–29.0 ± 19.4%) showed a strong correlation with resting VO₂ (r = 0.770, p < 0.001). Consequently, regardless of preoperative resting VO₂, intraoperative VO₂ converged to a relatively narrow range, averaging 1.1 ± 0.2 METs. In patients undergoing lung resection, intraoperative VO₂ converged to approximately 1 MET under general anesthesia, largely independent of preoperative resting metabolism. The clinical implications of this observation remain unclear and warrant investigation in larger prospective studies incorporating concurrent measurements of oxygen delivery and clinical outcomes.
Oh et al. (Thu,) conducted a observational in Lung resection surgery (n=32). General anesthesia vs. Preoperative resting state was evaluated on Correlation between resting oxygen consumption (VO2) and the reduction from resting to intraoperative VO2 (r = 0.770, p=<0.001). In patients undergoing lung resection, intraoperative oxygen consumption converged to approximately 1.1 METs under general anesthesia, representing a 29.0% reduction from resting levels.