Background Long noncoding RNAs (LncRNAs) have an impact on gene expression regulation with dysregulated expression in different cancers. T-cell leukemia/lymphoma 6 (TCL6) is an LncRNA that was thought to participate in leukemogenesis. Limited studies assessed LncRNAs differential expression among adult acute lymphoblastic leukemia (ALL). The purpose of the study was to investigate the correlation between LncRNA TCL6 expression and the clinical outcome among adult ALL patients. Materials and methods Bone marrow mononuclear cells were analyzed for LncRNA TCL6 expression by real-time quantitative PCR in forty newly diagnosed ALL cases and forty healthy individuals as controls. Results LncRNA TCL6 was underexpressed significantly in ALL patients (P = 0.003). Cases with high expression of TCL6 showed a higher incidence of complete remission (45.5%) compared to cases with low expression of TCL6 (44.8%), but the difference was not statistically significant (P = 0.814). Regarding overall survival, overexpressed cases of TCL6 showed better survival, but not statistically significant (P = 0.873). Conclusion LncRNA TCL6 underexpression is suggested to have a role in tumorigenesis and might be used to complement current cytogenetic and molecular biology analyses applied in the diagnosis of adult ALL. More studies are needed to determine its significance regarding the clinical outcome of adult ALL patients.
Imbaby et al. (Thu,) studied this question.
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