The PON1 Q192R polymorphism showed a non-significant association with the presence of coronary artery disease (OR 0.511, p=0.0632) in the North Macedonian population.
Cross-Sectional (n=165)
No
Does the PON1 Q192R gene polymorphism associate with the occurrence of coronary artery disease and need for stenting in a North Macedonian population?
The PON1 Q192R polymorphism showed a significant association with the need for stenting but not overall CAD presence, suggesting it may relate more to disease severity or vascular response than disease initiation.
Effect estimate: OR 0.511 (95% CI 0.25-0.595)
p-value: p=0.0632
Abstract Aim This study aims to examine the association between the prevalence of Q192R polymorphism of PON1 gene and the occurrence of atherosclerosis and coronary artery disease in patients in Republic of North Macedonia. Method This cross-sectional study includes subjects undergoing percutaneous coronary angiography with or without stenting due to monitoring of stable angina or induced ischemia, divided into two groups. Q192R polymorphism and its genotypic variants were analysed. The Polymerase Chain Reaction technique was used as a method for determining the single nucleotide polymorphism. Results A total of 165 subjects (106 belonging to the coronary artery disease (CAD) group and 59 to non-CAD group were evaluated in terms of their biochemical parameters and genetic variants. Results of the PON1 SNP Q192R groups (QQ, QR and RR) association related to CAD and non-CAD groups, resulted in a non-significant association (p=0.0632, OR=0.511, CI: 0.25–0.595, χ 2 =3.4508, df=1). In further analyses, to obtain a more precise association, we analysed the association between SNP Q192R groups and stenting patients (control vs. stenting group). Further analysis confirmed the association of QQ vs. QR and control vs. stenting (p=0.0418, OR=0.461, CI: 0.216–0.589, χ 2 =4.1432, df=1). Conclusion Results support the concept that genetic variants may contribute to an increased risk of CAD, emphasizing the importance of combined biochemical and genetic testing for better stratification of cardiovascular risk and early confirmation of the predisposition to develop serious cardiovascular disease. Further studies with a larger sample size are needed before Q192R gene polymorphism can be considered as a genetic risk factor for CAD.
Jakimovska et al. (Mon,) conducted a cross-sectional in Coronary Artery Disease (n=165). PON1 Q192R polymorphism (QQ vs QR+RR) vs. Non-CAD control group was evaluated on Association of PON1 Q192R polymorphism (QQ vs QR+RR) with coronary artery disease (OR 0.511, 95% CI 0.25-0.595, p=0.0632). The PON1 Q192R polymorphism showed a non-significant association with the presence of coronary artery disease (OR 0.511, p=0.0632) in the North Macedonian population.