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Circular RNAs (circRNAs) are a class of non-coding RNAs that play vital roles in cancer biology. However, the potential role of hsacircRNA₀088036 in bladder cancer (BCa) remains unknown. HsacircRNA₀088036 was identified by microarray analysis and validated by quantitative real-time polymerase chain reaction. Functional assays were conducted to confirm the effects of hsacircRNA₀088036 on the growth, migration, invasion, tumorigenesis, and metastasis of BCa cells. The luciferase reporter assay and RNA pull down assay were performed to investigate the interactions between hsacircRNA₀088036, miR-140-3p, and forkhead box protein Q1 (FOXQ1). Upregulated expression of hsacircRNA₀088036 in BCa tissues and cell lines was positively correlated with overall survival and clinicopathologic characteristics. Knockdown of hsacircRNA₀088036 inhibited the growth, migration, and invasion of BCa cells both in vivo and in vitro. Mechanistically, hsacircRNA₀088036 could directly interact with miR-140-3p and act as a miRNA sponge to modulate FOXQ1 expression. Knockdown of hsacircRNA₀088036 inhibited the proliferation, migration, and metastasis of BCa cells via miR-140-3p/FOXQ1 signaling, suggesting that hsacircRNA₀088036 is a potential biomarker and therapeutic target for BCa.
Yang et al. (Fri,) studied this question.